Phenotypes Associated with This Genotype

Genotype
MGI:6450919

• Allelic Composition: Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu}; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Tg(Wnt1-GAL4)11Rth/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

small frontonasal prominence ( J:284772 )

• at E15.5

small mandibular prominence ( J:284772 )

• at E15.5

small maxillary prominence ( J:284772 )

• at E15.5

absent nasal capsule ( J:284772 )

abnormal face development ( J:284772 )

• undersized facial primordia at E10.5

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

midline facial cleft ( J:284772 )

• at E15.5

growth/size/body

absent nasal capsule ( J:284772 )

abnormal face development ( J:284772 )

• undersized facial primordia at E10.5

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

midline facial cleft ( J:284772 )

• at E15.5

abnormal head mesenchyme morphology ( J:284772 )

• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice

• however, there is no difference in centriole number

embryo

abnormal head mesenchyme morphology ( J:284772 )

• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice

• however, there is no difference in centriole number

digestive/alimentary system

abnormal stomodeum morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

nervous system

abnormal brain morphology ( J:284772 )

• brain is shifted rostrally

respiratory system

absent nasal capsule ( J:284772 )

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

skeleton

absent nasal capsule ( J:284772 )

nasal septum cartilage hypoplasia ( J:284772 )

• severe

taste/olfaction

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity