Phenotypes Associated with This Genotype

Genotype
MGI:6450125

• Allelic Composition: Cx3cr1^{tm2.1(cre/ERT2)Litt}/Cx3cr1⁺; Vps35^{Gt(RRK261)Byg}/Vps35^{Gt(RRK261)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased neuron apoptosis ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

hematopoietic system

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased macrophage cell number ( J:292365 )

• increased number of macrophages in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of macrophages in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

homeostasis/metabolism

increased transforming growth factor beta level ( J:292365 )

• increased expression of TGFB in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased cerebral infarct size ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

immune system

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased macrophage cell number ( J:292365 )

• increased number of macrophages in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of macrophages in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased interleukin-1 beta secretion ( J:292365 )

• reduced expression of IL1B in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased interleukin-10 secretion ( J:292365 )

• increased expression of IL10 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased interleukin-4 secretion ( J:292365 )

• increased expression of IL4 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased interleukin-6 secretion ( J:292365 )

• reduced expression of IL6 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased tumor necrosis factor secretion ( J:292365 )

• reduced expression of TNFA in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:292365 )

• decreased cortex infarction size after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased neuronal cell death after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

• lower increase of astrocyte number (reduced astrocytosis) in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• reduced number of pro-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

nervous system

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased neuron apoptosis ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

decreased cerebral infarct size ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout