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Phenotypes Associated with This Genotype
Genotype
MGI:6444814
Allelic
Composition		 Coro1ctm1c(KOMP)Wtsi/Coro1ctm1c(KOMP)Wtsi
Ptentm2Mak/Ptentm2Mak
Trp53tm1Brn/Trp53tm1Brn
Tg(GFAP-cre/Esr1*,-lacZ)ASbk/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coro1ctm1c(KOMP)Wtsi mutation (0 available); any Coro1c mutation (69 available)
Ptentm2Mak mutation (4 available); any Pten mutation (87 available)
Tg(GFAP-cre/Esr1*,-lacZ)ASbk mutation (1 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:290447 )
• as in mice with wild-type Coro1c in tamoxifen-treated mice

neoplasm
increased glioblastoma incidence ( J:290447 )
• as in mice with wild-type Coro1c in tamoxifen-treated mice

nervous system
increased glioblastoma incidence ( J:290447 )
• as in mice with wild-type Coro1c in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory