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Phenotypes Associated with This Genotype
Genotype
MGI:6444642
Allelic
Composition		 Fis1tm1.1Itl/Fis1tm1.1Itl
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6NCrlj * C57BL/6NTac * DBA/2 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fis1tm1.1Itl mutation (0 available); any Fis1 mutation (47 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagy ( J:290485 )
• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice

homeostasis/metabolism
abnormal autophagy ( J:290485 )
• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory