Phenotypes Associated with This Genotype

Genotype
MGI:6443613

• Allelic Composition: Tg(Tk1-DPP4)27Ysj/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal chemokine level ( J:290259 )

• MIP-1alpha is increased in the liver, lung, and spleen of MERS-CoV-infected mice at 4 and 6 dpi

abnormal interleukin level ( J:290259 )

• Il-1beta mRNA levels are elevated in the lung and spleen at 6 dpi

abnormal tumor necrosis factor level ( J:290259 )

• TNF-alpha mRNA levels are elevated in the lung and spleen at 4 and 6 dpi

lung inflammation ( J:290259 )

• MERS-CoV-infected mice show mild inflammation with inflammatory cell infiltration into the lung, including infiltration of activated macrophages at 6 dpi

abnormal innate immunity ( J:290259 )

• MERS-CoV-infected mice show an enhanced systemic innate inflammatory response with an increase in proinflammatory cytokine and chemokine expression in the spleen and macrophage infiltration in the lungs

abnormal macrophage activation involved in immune response ( J:290259 )

• mice exhibit polarized activation of macrophages in the lungs following MERS-CoV infection

increased susceptibility to Coronaviridae infection ( J:290259 )

• mice intranasally infected with the Middle East respiratory syndrome coronavirus (MERS-CoV; 1-001-MERS-IS-2015001 from the Korea Centers for Disease Control and Prevention) are permissive to infection and show increased morbidity, mortality, and proinflammatory cytokine and chemokine expression

• viral RNA levels increased in the brain, spleen, and intestine at 6 dpi of MERS-CoV-infected mice, however, only low or unchanged viral gene expression is seen in the liver

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:290259 )

• MERS-CoV-infected mice show increased mortality with 40% and 100% mortality at 6 dpi and 7 dpi, respectively

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:290259 )

• MERS-CoV-infected mice show increased mortality with 40% and 100% mortality at 6 dpi and 7 dpi, respectively

growth/size/body

increased susceptibility to weight loss ( J:290259 )

• MERS-CoV-infected mice develop acute respiratory and wasting syndromes with rapid weight loss at 4 to 6 days post infection (dpi)

respiratory system

lung hemorrhage ( J:290259 )

• focal hemorrhage in the interstitium is seen at 6 dpi with MERS-CoV

lung inflammation ( J:290259 )

• MERS-CoV-infected mice show mild inflammation with inflammatory cell infiltration into the lung, including infiltration of activated macrophages at 6 dpi

abnormal lung morphology ( J:290259 )

• MERS-CoV-infected mice show irregular arrangement of pneumocytes and alveolar septal changes, progressive lung damage with alveolar septal thickening

pulmonary fibrosis ( J:290259 )

• mice exhibit progressive pulmonary fibrosis following MERS-CoV infection

hyperpnea ( J:290259 )

• MERS-CoV-infected mice exhibit more rapid breathing than controls

cardiovascular system

lung hemorrhage ( J:290259 )

• focal hemorrhage in the interstitium is seen at 6 dpi with MERS-CoV

hematopoietic system

abnormal macrophage activation involved in immune response ( J:290259 )

• mice exhibit polarized activation of macrophages in the lungs following MERS-CoV infection

homeostasis/metabolism

abnormal chemokine level ( J:290259 )

• MIP-1alpha is increased in the liver, lung, and spleen of MERS-CoV-infected mice at 4 and 6 dpi

abnormal interleukin level ( J:290259 )

• Il-1beta mRNA levels are elevated in the lung and spleen at 6 dpi

abnormal tumor necrosis factor level ( J:290259 )

• TNF-alpha mRNA levels are elevated in the lung and spleen at 4 and 6 dpi

increased transforming growth factor beta level ( J:290259 )

• lungs of MERS-CoV-infected mice show increased TGF-beta1 expression, peaking at 4 dpi and decreased at 6 dpi

integument

ruffled hair ( J:290259 )

• MERS-CoV-infected mice exhibit ruffled or sweaty fur

nervous system

convulsive seizures ( J:290259 )

• MERS-CoV-infected mice show convulsions

behavior/neurological

decreased locomotor activity ( J:290259 )

• MERS-CoV-infected mice exhibit inactivity

convulsive seizures ( J:290259 )

• MERS-CoV-infected mice show convulsions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Middle East respiratory syndrome		DOID:0080642		J:290259