Phenotypes Associated with This Genotype

Genotype
MGI:6441188

• Allelic Composition: Dgkg^tm1Yash/Dgkg^tm1Yash
• Genetic Background: involves: C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:288365 )

• significantly more slips in the balance beam test

• significantly shorter latency to fall in rotarod test

short stride length ( J:288365 )

• significantly (~15%) shorter stride length of hind paws in footprint test

nervous system

abnormal Purkinje cell dendrite morphology ( J:288365 )

• reduced number of dendrite branches and total dendrite length

• fewer branches in distal dendrites at distances of 120, 140, and 150 mm from the soma according to Sholl analysis

• normal number of dendrites per cell

abnormal nervous system electrophysiology ( J:288365 )

• significantly lower membrane capacitance of distal region of Purkinje cell dendrites

• normal membrane capacitance of proximal region of Purkinje cell dendrites and soma

increased excitatory postsynaptic current amplitude ( J:288365 )

• after applying conjunctive stimulus (CJS) to parallel fibers (PFs)

absent long-term depression ( J:288365 )

• after applying conjunctive stimulus (CJS) to parallel fibers (PFs)