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Phenotypes Associated with This Genotype
Genotype
MGI:6430488
Allelic
Composition
Ifngtm1Yiw/Ifngtm1Yiw
Genetic
Background
C.129X1-Ifngtm1Yiw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Yiw mutation (4 available); any Ifng mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• JHMV infected mice show increased levels of IFN activity; similar level of IFN activity is seen on the BALB/c background as on C57BL/6 background
• Background Sensitivity: viral titer of JHMV infected mice is 20- and 6-fold higher than in heterozygotes at 3 and 5 dpi, respectively, on a BALB/c background compared to a much lower viral titer in mice on a BALB/c background
• Background Sensitivity: mice infected with the DL variant of the coronavirus mouse hepatitis virus (JHMV) die within 1 week after infection when on a BALB/c background compared to longer survival on a C57BL/6 background
• JHMV-infected mice treated with exogenous IFN-gamma show increased survival rate

mortality/aging
• Background Sensitivity: mice infected with the DL variant of the coronavirus mouse hepatitis virus (JHMV) die within 1 week after infection when on a BALB/c background compared to longer survival on a C57BL/6 background
• JHMV-infected mice treated with exogenous IFN-gamma show increased survival rate

liver/biliary system
• Background Sensitivity: JHMV infected mice show massive liver necrosis at 5 days post infection (dpi) on a BALB/c background compared to only focal necrotic lesion in mice on a C57BL/6 background

homeostasis/metabolism
• JHMV infected mice show increased levels of IFN activity; similar level of IFN activity is seen on the BALB/c background as on C57BL/6 background
• Background Sensitivity: JHMV infected mice show a much greater increase in serum ALT activity at 3 and 5 dpi on the BALB/c background compared to only a slight rise on the C57BL/6 background

cellular
• Background Sensitivity: JHMV infected mice show massive liver necrosis at 5 days post infection (dpi) on a BALB/c background compared to only focal necrotic lesion in mice on a C57BL/6 background


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory