Phenotypes Associated with This Genotype

Genotype
MGI:6430488

• Allelic Composition: Ifng^tm1Yiw/Ifng^tm1Yiw
• Genetic Background: C.129X1-Ifng^tm1Yiw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal circulating interferon level ( J:91691 )

• JHMV infected mice show increased levels of IFN activity; similar level of IFN activity is seen on the BALB/c background as on C57BL/6 background

increased susceptibility to Coronaviridae infection ( J:91691 )

• Background Sensitivity: viral titer of JHMV infected mice is 20- and 6-fold higher than in heterozygotes at 3 and 5 dpi, respectively, on a BALB/c background compared to a much lower viral titer in mice on a BALB/c background

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:91691 )

• Background Sensitivity: mice infected with the DL variant of the coronavirus mouse hepatitis virus (JHMV) die within 1 week after infection when on a BALB/c background compared to longer survival on a C57BL/6 background

• JHMV-infected mice treated with exogenous IFN-gamma show increased survival rate

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:91691 )

• Background Sensitivity: mice infected with the DL variant of the coronavirus mouse hepatitis virus (JHMV) die within 1 week after infection when on a BALB/c background compared to longer survival on a C57BL/6 background

• JHMV-infected mice treated with exogenous IFN-gamma show increased survival rate

liver/biliary system

diffuse hepatic necrosis ( J:91691 )

• Background Sensitivity: JHMV infected mice show massive liver necrosis at 5 days post infection (dpi) on a BALB/c background compared to only focal necrotic lesion in mice on a C57BL/6 background

homeostasis/metabolism

abnormal circulating interferon level ( J:91691 )

• JHMV infected mice show increased levels of IFN activity; similar level of IFN activity is seen on the BALB/c background as on C57BL/6 background

increased circulating alanine transaminase level ( J:91691 )

• Background Sensitivity: JHMV infected mice show a much greater increase in serum ALT activity at 3 and 5 dpi on the BALB/c background compared to only a slight rise on the C57BL/6 background

cellular

diffuse hepatic necrosis ( J:91691 )

• Background Sensitivity: JHMV infected mice show massive liver necrosis at 5 days post infection (dpi) on a BALB/c background compared to only focal necrotic lesion in mice on a C57BL/6 background