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Phenotypes Associated with This Genotype
Genotype
MGI:6430478
Allelic
Composition
Ifngtm1Yiw/Ifngtm1Yiw
Genetic
Background
B6.129X1-Ifngtm1Yiw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Yiw mutation (4 available); any Ifng mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• JHMV infected mice develop peritonitis at 21 dpi
• JHMV infection is characterized by disseminated granulomatous inflammation and exudative fibrinous serositis with plasma cells and eosinophils in the abdominal cavity and these same lesions in the thoracic cavity
• JHMV infected mice show increased levels of IFN activity; similar level of IFN activity is seen on the C57BL/6 background as on BALB/c background
• mice injected with an anti-CD8 monoclonal antibody to deplete CD8+ T cells and then infected with JHMV develop severe hepatitis and die within 2 weeks
• however, JHMV infected mice without depletion of CD8+ T cells do not develop hepatitis
• mice show increased susceptibility to infection with murine coronavirus strain JHM (hepatitis mouse virus) , showing higher viral titers at 3 and 5 dpi with a gradual decrease but persistence of virus in the liver compared to viral clearing in the liver of controls, higher antibody titers and virus neutralization antibody tiers (J:50405)
• virus is recovered from various tissues, including the liver, spleen, kidney, pancreas, mesenterium and lung of some JHMV-infected mice at 21 dpi, with the highest level of viral growth in the mesenterium (J:50405)
• although both cell-mediated and humoral immune responses are activated during JHMV infection, JHMV persists in mice (J:50405)
• Background Sensitivity: viral titer of JHMV infected mice is slightly higher than in heterozygotes on a C57BL/6 background compared to a much higher viral titer in mice on a BALB/c background (J:91691)
• JHMV infected mice show some lethality at 16 days post infection (dpi), with survival rate gradually decreasing such that about 90% die by 50 dpi (J:50405)
• JHMV-infected mice treated with recombinant IFN-gamma show increases survival time (J:50405)
• Background Sensitivity: mice infected with the DL variant of the coronavirus mouse hepatitis virus (JHMV) show a gradual decrease in survival rate on the C57BL/6 background compared to lethality within 1 week on a BALB/c background (J:91691)

cellular
• Background Sensitivity: JHMV infected mice show only focal necrotic lesion in the liver at 5 days post infection (dpi) on a C57BL/6 background compared to massive liver necrosis on a BALB/c background

mortality/aging
• JHMV infected mice show some lethality at 16 days post infection (dpi), with survival rate gradually decreasing such that about 90% die by 50 dpi (J:50405)
• JHMV-infected mice treated with recombinant IFN-gamma show increases survival time (J:50405)
• Background Sensitivity: mice infected with the DL variant of the coronavirus mouse hepatitis virus (JHMV) show a gradual decrease in survival rate on the C57BL/6 background compared to lethality within 1 week on a BALB/c background (J:91691)

digestive/alimentary system
• JHMV infected mice develop peritonitis at 21 dpi
• JHMV infection is characterized by disseminated granulomatous inflammation and exudative fibrinous serositis with plasma cells and eosinophils in the abdominal cavity and these same lesions in the thoracic cavity

liver/biliary system
• mice injected with an anti-CD8 monoclonal antibody to deplete CD8+ T cells and then infected with JHMV develop severe hepatitis and die within 2 weeks
• however, JHMV infected mice without depletion of CD8+ T cells do not develop hepatitis
• JHMV infected mice show larger liver lesions that are infiltrated with neutrophils compared to wild-type infected mice
• some JHMV infected mice exhibit pseudomembrane on the surface of the liver at 14 dpi
• however, JHMV-infected mice do not develop severe hepatitis and alanine transaminase levels are similar to those in infected wild-type mice
• Background Sensitivity: JHMV infected mice show only focal necrotic lesion in the liver at 5 days post infection (dpi) on a C57BL/6 background compared to massive liver necrosis on a BALB/c background

homeostasis/metabolism
• JHMV infected mice show increased levels of IFN activity; similar level of IFN activity is seen on the C57BL/6 background as on BALB/c background
• about 50% of JHMV infected mice exhibit accumulation of ascites fluid at P21
• however, no bacteria is isolated from ascites fluid

growth/size/body
• some JHMV infected mice exhibit organs in abdominal cavities that adhere to each other and the peritoneum
• JHMV infected mice show accumulatio of a translucent fluid in the thoracic cavity in the subacute phase

behavior/neurological
• a small number of JHMV infected mice show signs of central nervous system disease such as inability to turn over rapidly


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory