Phenotypes Associated with This Genotype

Genotype
MGI:6416347

• Allelic Composition: Hgd^{tm1c(KOMP)Wtsi}/Hgd^{tm1c(KOMP)Wtsi}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:287389 )

• mice injected with pIpC show increased plasma homogentisic acid (HGA) levels

abnormal urine homeostasis ( J:287389 )

• mice show a relatively small increase in urinary HGA following pIpC injection

renal/urinary system

abnormal urine homeostasis ( J:287389 )

• mice show a relatively small increase in urinary HGA following pIpC injection

skeleton

abnormal articular cartilage morphology ( J:287389 )

• few or no pigmented chondrons are seen in the calcified articular cartilage of knee joints at 9 weeks post pIpC injection, but increased numbers are seen at 15 and 20 weeks post pIpC