Phenotypes for App Mapt MGI:6414671 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	App^tm3.1Tcs/App^tm3.1Tcs Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs}
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm3.1Tcs mutation (2 available); any App mutation (118 available)
Mapt^{tm1.1(MAPT)Tcs} mutation (4 available); any Mapt mutation (453 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:278451 )

• mice exhibit similar neuronal cell death as in single App^tm3.1Tcs mutants

amyloid beta deposits ( J:278451 )

• mice exhibit similar amyloid pathology as in single App^tm3.1Tcs mutants

CNS inflammation ( J:278451 )

• mice exhibit similar neuroinflammation as in single App^tm3.1Tcs mutants

cellular