About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6406420
Allelic
Composition
Epha4tm1.1Bzh/Epha4tm1.1Bzh
Isl1tm1(cre)Sev/Isl1+
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6J * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1.1Bzh mutation (1 available); any Epha4 mutation (68 available)
Isl1tm1(cre)Sev mutation (1 available); any Isl1 mutation (38 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• embryos show an increase in the number of abducens nerve bundles following exit from the hindbrain, reductions in both abducens nerve length and diameter at the orbit and larger wandering abducens nerve bundles that exhibit enhanced nerve pausing at the midpoint decision within the abducens fasciculation region
• however, trochlear nerve and first cervical spine projections are normal
• abducens nerve length is reduced and nerve diameter is thinner near the orbit in embryos


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/30/2025
MGI 6.24
The Jackson Laboratory