Phenotypes Associated with This Genotype

Genotype
MGI:6401286

• Allelic Composition: Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal epithelium physiology ( J:285672 )

• cultured crypts from tamoxifen-tested mice exhibit poor organoid growth compared with control cells

• crypts of tamoxifen-treated mice exhibit increased DNA damage from cloxP cleavage compared with control crypts

• however, mice exhibit normal enterocyte proliferation and apoptosis and restored regeneration after 7 days following irradiation

delayed intestine regeneration ( J:285672 )

• delayed intestine regeneration in tamoxifen-treated mice following challenge with 12 Gy irradiation

• however, mice not treated with tamoxifen exhibit normal response to irradiation

growth/size/body

increased susceptibility to weight loss ( J:285672 )

• increased weight loss in tamoxifen-treated mice following challenge with 12 Gy irradiation

• however, mice not treated with tamoxifen exhibit normal response to irradiation

homeostasis/metabolism

abnormal response to radiation ( J:285672 )

• following challenge with 12 Gy irradiation, tamoxifen-treated mice exhibit increased weight loss and intestinal damage with extensive decellularization of crypts, few crypt structures, and delayed regeneration compared with control mice

• however, mice not treated with tamoxifen exhibit normal response to irradiation