Phenotypes Associated with This Genotype

Genotype
MGI:6401148

• Allelic Composition: Ighg1^tm1(cre)Cgn/0; Mef2b^tm2Rdf/Mef2b⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ and increased number in LZ

immune system

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ and increased number in LZ