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Phenotypes Associated with This Genotype
Genotype
MGI:6401139
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (4 available); any Ighg1 mutation (29 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
decreased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system
abnormal mature B cell morphology ( J:265465 )
• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
decreased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory