Phenotypes Associated with This Genotype

Genotype
MGI:6400959

• Allelic Composition: Tardbp^Rgsc2223/Tardbp^Rgsc2223
• Genetic Background: involves: C57BL/6JJcl * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:265666 )

• 38% reduction in tetanic strength in tibialis anterior muscles at age 24 month

• progressive grip strength deficit from age 12 months

mortality/aging

mortality/aging ( J:265666 )

N • viable

nervous system

decreased motor neuron number ( J:265666 )

• 28% reduction in sciatic MNs at L4-L5 at age 24 months

• 15% reduction in motor units innervating extensor digitorum (EDL) muscle at age 24 months