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Phenotypes Associated with This Genotype
Genotype
MGI:6393921
Allelic
Composition		 Braftm1Mmcm/Braf+
Ezh2tm1.1Nesh/Ezh2+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (4 available); any Braf mutation (61 available)
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased melanoma incidence ( J:239472 )
• tamoxifen-treated mice show accelerated tumorigenesis of unpigmented, nonmetastatic melanoma compared to single Braf conditional mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory