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Phenotypes Associated with This Genotype
Genotype
MGI:6393694
Allelic
Composition		 Ezh2tm1.1Nesh/Ezh2tm1.1Nesh
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:239472 )
• development of B cell lymphoma with kinetics and tumor immunophenotype nearly identical to heterozygous conditional mutants

immune system
enlarged lymph nodes ( J:239472 )
• lymphadenopathy with an infiltration of abnormal B220lowMac2low B cells

hematopoietic system

growth/size/body
enlarged spleen ( J:239472 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory