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Phenotypes Associated with This Genotype
Genotype
MGI:6393270
Allelic
Composition		 Dhx15tm1c(EUCOMM)Wtsi/Dhx15tm1c(EUCOMM)Wtsi
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Dhx15tm1c(EUCOMM)Wtsi mutation (0 available); any Dhx15 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:284624 )
• in a competitive fitness assay upon activation
decreased B cell number ( J:284624 )
• 4-fold reduction, not restricted to a particular B cell subtype
• 4-fold reduction of CD3+ splenic B cells
decreased pre-B cell number ( J:284624 )
• in the bone marrow

cellular
decreased B cell proliferation ( J:284624 )
• in a competitive fitness assay upon activation

hematopoietic system
decreased B cell proliferation ( J:284624 )
• in a competitive fitness assay upon activation
decreased B cell number ( J:284624 )
• 4-fold reduction, not restricted to a particular B cell subtype
• 4-fold reduction of CD3+ splenic B cells
decreased pre-B cell number ( J:284624 )
• in the bone marrow

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory