Phenotypes Associated with This Genotype

Genotype
MGI:6392034

• Allelic Composition: Hnrnpf^tm1Jsdc/Hnrnpf^tm1Jsdc; Pax8^{tm1.1(cre)Mbu}/Pax8⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypertension ( J:284239 )

• mice develop hypertension by 8 weeks of age

increased systemic arterial systolic blood pressure ( J:284239 )

• mice exhibit higher systolic blood pressure from 6 to 24 weeks of age

homeostasis/metabolism

increased angiotensin II level ( J:284239 )

• increase in urinary angiotensin II levels at 24 weeks of age

abnormal urine homeostasis ( J:284239 )

• increase in urinary angiotensin II levels at 24 weeks of age

increased urine glucose level ( J:284239 )

• increase in glucose excretion in the urine at 6 weeks of age, indicating development of glycosuria

• from 8 weeks of age, urinary glucose levels in males decrease and return to levels similar to wild-type mice at 12 weeks of age

• urinary glucose excretion in females steadily increases from week 6, reaches a plateau at 12 weeks of age and does not abate

• however, mice exhibit normal non-fasting blood glucose levels and normal glucose tolerance at 23 weeks of age

albuminuria ( J:284239 )

• increase in urinary albumin/creatinine ratio at 24 weeks of age

renal/urinary system

abnormal urine homeostasis ( J:284239 )

• increase in urinary angiotensin II levels at 24 weeks of age

increased urine glucose level ( J:284239 )

• increase in glucose excretion in the urine at 6 weeks of age, indicating development of glycosuria

• from 8 weeks of age, urinary glucose levels in males decrease and return to levels similar to wild-type mice at 12 weeks of age

• urinary glucose excretion in females steadily increases from week 6, reaches a plateau at 12 weeks of age and does not abate

• however, mice exhibit normal non-fasting blood glucose levels and normal glucose tolerance at 23 weeks of age

albuminuria ( J:284239 )

• increase in urinary albumin/creatinine ratio at 24 weeks of age

renal interstitial fibrosis ( J:284239 )

• tubule-interstitial fibrosis is seen in the kidneys at 24 weeks of age

abnormal renal tubule morphology ( J:284239 )

• increase of tubular luminal area

• however, mice show no obvious structural changes in the kidneys at 24 weeks of age, normal kidney weight/body weight ratio, normal glomerular filtration rate, and normal glomerular tuft volume

abnormal proximal convoluted tubule morphology ( J:284239 )

• increase of renal proximal tubular cell volume

polyuria ( J:284239 )

• 24 hour urine volume is increased

• however, food and water intake are normal and no differences in serum and urine levels of sodium, calcium, and phosphorus are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
renal glycosuria		DOID:9432	OMIM:233100	J:284239