Phenotypes for Cd19 Map3k14 Otub1 MGI:6387022 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Map3k14^tm1.1Gne/Map3k14^tm1.1Gne Otub1^{tm1c(EUCOMM)Hmgu}/Otub1^{tm1c(EUCOMM)Hmgu} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * C57BL/6NTac
Cell Lines	HEPD0539_8_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Map3k14^tm1.1Gne mutation (0 available); any Map3k14 mutation (42 available)
Otub1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Otub1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:280549 )

N	• mice show a rescue of the B-cell defect seen in Otub1 conditional mice, with mice showing enhanced frequency and absolute number of peritoneal B2 cells • mice show a rescue of the defect in B-cell maturation, with increased splenic mature B cells, particularly the MZ B cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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