Phenotypes Associated with This Genotype

Genotype
MGI:6385861

• Allelic Composition: Hspd1^{tm1c(EUCOMM)Hmgu}/Hspd1^{tm1c(EUCOMM)Hmgu}; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: Black Swiss * C3H * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:282096 )

• embryos are seen at the expected Mendelian ratio at E10.5 but all embryos between E11.5 and E13.5 are dead and absorbed

cardiovascular system

abnormal blood vessel morphology ( J:282096 )

• some vessels exhibit reduced diameters in the head, trunk, and yolk sac at E10.5 but not E9.5

• however, marker analysis shows that endothelial cell differentiation and early development of the yolk sac vascular system appear normal

embryo

embryonic growth retardation ( J:282096 )

• E10.5, but not E9.5, embryos are growth retarded

growth/size/body

embryonic growth retardation ( J:282096 )

• E10.5, but not E9.5, embryos are growth retarded

hematopoietic system

anemia ( J:282096 )

• E10.5 embryos develop severe anemia and are pale

abnormal blood cell morphology ( J:282096 )

• E10.5 embryos exhibit an abnormally low number of blood cells in embryos or yolk sacs

decreased erythrocyte cell number ( J:282096 )

• the numbers of yolk sac erythrocytes are reduced at E9

• however, blood distribution in yolk sacs is similar to controls at E8.5 and the numbers of yolk sac erythrocytes are normal at E8.5

abnormal erythrocyte physiology ( J:282096 )

• cell apoptosis of yolk sac erythrocytes is increased at E9 but not E8.5

• treatment with cyclosporine A decreases erythrocyte cell apoptosis

• mitochondrial membrane potentials of Ter119+ erythrocytes from E8.5 yolk sacs are slightly, but significantly, lower than in controls