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Phenotypes Associated with This Genotype
Genotype
MGI:6384868
Allelic
Composition		 Nlrp3tm2Hhf/Nlrp3tm2Hhf
Vsig4tm1Gne/Vsig4tm1Gne
Genetic
Background		 B6.Cg-Nlrp3tm2Hhf Vsig4tm1Gne
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm2Hhf mutation (1 available); any Nlrp3 mutation (69 available)
Vsig4tm1Gne mutation (0 available); any Vsig4 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )
• MOG35-55 treated mice exhibit reduced clinical score compared with Vsig4tm1Gne homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory