Phenotypes Associated with This Genotype

Genotype
MGI:6384690

• Allelic Composition: Onecut1^tm1.1Mga/Onecut1^tm1.1Mga; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:200752 )

N • normal location, morphology and number of rods, cones, bipolar, Mueller, amacrine, and retinal ganglion cells at age P16 and 3 months

N • normal retinal outer (ONL) and inner (INL) nuclear layer and retinal inner plexiform (IPL) and ganglion cell (GCL) layer morphology at age P16

N • normal levels of apoptosis in retina at ages E14.5, E17.5 and P0

thin retina outer nuclear layer ( J:200752 )

• slightly thinner at age 5 months

• around 3x thinner at age 8 months

disorganized retina outer nuclear layer ( J:200752 )

• less tightly packed at age 5 months

retina outer nuclear layer degeneration ( J:200752 )

• slightly thinner at age 5 months

• around 3x thinner at age 8 months

abnormal retina outer plexiform layer morphology ( J:200752 )

• larger spaces between horizontal cells (HCs) with longer and thicker processes at age P16 and 3 months

• 85% reduction in Lim1+ HC precursors at age E14.5 and HCs at age E17.5

• normal non-random mosaic distribution pattern at age P16

thin retina outer plexiform layer ( J:200752 )

• thinner and sometimes absent at age P16 and 3 months

• 74% reduction in number of horizontal cells (HCs) at age P16

• virtually absent at age 5 months

decreased a-wave amplitude ( J:200752 )

• much smaller across all light intensities using dark-adapted flash ERG at age 5 months

decreased b-wave amplitude ( J:200752 )

• much smaller across all light intensities using dark-adapted flash ERG at age 5 months

• around 3x smaller across all light intensities using light-adapted flash ERG at age 5 months

• normal time to peak