Phenotypes Associated with This Genotype

Genotype
MGI:6384017

• Allelic Composition: Kras^tm4Tyj/Kras^tm4Tyj; Ptpn11^tm1Gsf/Ptpn11^tm1Gsf; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:174095 )

N • normal retina morphology at age P21 and P120

N • normal optic nerve morphology at age P21 and P120

decreased a-wave amplitude ( J:174095 )

• with scotopic ERG using very bright flashes at age 3 months, but not as severe as mice with wildtype Kras allele

decreased b-wave amplitude ( J:174095 )

• with scotopic ERG using dim flashes at age 3 months, but not as severe as mice with wildtype Kras allele

• with photopic ERG using double flashes at age 3 months, but not as severe as mice with wildtype Kras allele

abnormal cone electrophysiology ( J:174095 )

• reduced b wave amplitude with photopic ERG using double flashes at age 3 months, but not as severe as mice with wildtype Kras allele

abnormal rod electrophysiology ( J:174095 )

• reduced saturated a wave amplitude with scotopic ERG using very bright flashes at age 3 months, but not as severe as mice with wildtype Kras allele

• reduced b wave amplitude with scotopic ERG using dim flashes at age 3 months, but not as severe as mice with wildtype Kras allele