Phenotypes Associated with This Genotype

Genotype
MGI:6384015

• Allelic Composition: Ptpn11^tm1Gsf/Ptpn11^tm1Gsf; Stat3^tm1Xyfu/Stat3^tm1Xyfu; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina ganglion cell degeneration ( J:174095 )

• much thinner at age P21, more severe than in mice with wildtype Stat3 allele

thin retina ganglion layer ( J:174095 )

• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele

thin retina inner nuclear layer ( J:174095 )

• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele

thin retina outer nuclear layer ( J:174095 )

• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele

retina outer nuclear layer degeneration ( J:174095 )

• much thinner at age P21, more severe than in mice with wildtype Stat3 allele

thin retina outer plexiform layer ( J:174095 )

• largely disappeared at age P21, more severe than in mice with wildtype Stat3 allele

retina degeneration ( J:174095 )

• much thinner at age P21, more severe than in mice with wildtype Stat3 allele

nervous system

retina ganglion cell degeneration ( J:174095 )

• much thinner at age P21, more severe than in mice with wildtype Stat3 allele