Phenotypes Associated with This Genotype

Genotype
MGI:6383435

• Allelic Composition: Nrf1^{tm1c(KOMP)Wtsi}/Nrf1^{tm1c(KOMP)Wtsi}; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:267504 )

• disrupted and acellular central region near the optic disc

abnormal retina progenitor cell morphology ( J:267504 )

• severe reduction in proliferation at E13.5

abnormal retina layer morphology ( J:267504 )

• large sub-retinal space between the retina and pigmented epithelium

abnormal retina neuronal layer morphology ( J:267504 )

• reduced cell numbers in all cellular layers at P20 and 7 months of age

• disrupted laminar layers at 7 months of age

decreased retina ganglion cell number ( J:267504 )

• few Isl1+ retinal ganglion cells at E12.5

• few Pou4f2+ retinal ganglion cells

• at E16.5, newly differentiated retinal ganglion cells spread to the peripheral region failing to migrate toward the vitreous layer

absent retina ganglion layer ( J:267504 )

• near complete abolishment as early as E14.5

thin retina ganglion layer ( J:267504 )

• at E16.5

decreased total retina thickness ( J:267504 )

• small and thin at E16.5

• at P20

retina hypoplasia ( J:267504 )

• at P20 and 7 months of age

cellular

abnormal axon extension ( J:267504 )

• defective axon outgrowth in E13.5 retinal explants

nervous system

abnormal axon extension ( J:267504 )

• defective axon outgrowth in E13.5 retinal explants

decreased retina ganglion cell number ( J:267504 )

• few Isl1+ retinal ganglion cells at E12.5

• few Pou4f2+ retinal ganglion cells

• at E16.5, newly differentiated retinal ganglion cells spread to the peripheral region failing to migrate toward the vitreous layer