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Phenotypes Associated with This Genotype
Genotype
MGI:6382534
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Tg(OPN1LW-cre)4Yzl/0
Genetic
Background		 involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Tg(OPN1LW-cre)4Yzl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina cone cell degeneration ( J:282245 )
• cone cell loss in 3 month old mice
• however, overall morphology and structural integrity of retinas is normal at 3 months of age
decreased b-wave amplitude ( J:282245 )
• photopic ERG b-wave recordings of cone photoreceptors are lower at 3 months of age
• however, scotopic ERG recordings of rod photoreceptors are normal at 3 months of age

nervous system
retina cone cell degeneration ( J:282245 )
• cone cell loss in 3 month old mice
• however, overall morphology and structural integrity of retinas is normal at 3 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory