Phenotypes Associated with This Genotype

Genotype
MGI:6379400

• Allelic Composition: Fzd5^tm1Mmt/Fzd5^tm1Cle; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:142601 )

N • mice exhibit normal optic fissure closure at E14.5

increased cornea thickness ( J:142601 )

• at E14.5

small lens ( J:142601 )

• variable and not highly significant reduction in diameter

microphthalmia ( J:142601 )

abnormal retina layer morphology ( J:142601 )

• abnormal lamination in some mice especially in the inner retinas and rosette structures

• however, retina distant from the hyperplastic vitreous vasculature is normal

disorganized retina ganglion layer ( J:142601 )

• adjacent to the hyperplastic vitreous vasculature mixed with neuroblast layer

increased total retina thickness ( J:142601 )

• at E14.5

retina detachment ( J:142601 )

• partial in some mice

• complete in some mice

retina fold ( J:142601 )

• retinal folds in some mice

vitreous body deposition ( J:142601 )

• retrolental mass at E12.5 and E17.5 that disrupts neuroblast lamination in the adjacent retinal area

abnormal eye physiology ( J:142601 )

• on going proliferation of hyperplastic vitreous vasculature

abnormal retina apoptosis ( J:142601 )

• increased apoptosis of ganglion cells adjacent to the hyperplastic vitreous vasculature, which fails to undergo apoptosis

cardiovascular system

abnormal vascular regression ( J:142601 )

• due to failure of vascular regression, the retrolental mass develops into pigmented hyperplastic primary vasculature that persists in postnatal stages (P0, P10 and P23) occasionally attached to the lens or the inner surface of the retina

cellular

abnormal vascular regression ( J:142601 )

• due to failure of vascular regression, the retrolental mass develops into pigmented hyperplastic primary vasculature that persists in postnatal stages (P0, P10 and P23) occasionally attached to the lens or the inner surface of the retina

abnormal retina apoptosis ( J:142601 )

• increased apoptosis of ganglion cells adjacent to the hyperplastic vitreous vasculature, which fails to undergo apoptosis