Phenotypes Associated with This Genotype

Genotype
MGI:6379273

• Allelic Composition: Magi1^tm1Itl/Magi1^tm1Itl; Nphs1^tm1Rkl/Nphs1⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased urine protein level ( J:237632 )

• At approximately 1 year of age

renal/urinary system

increased urine protein level ( J:237632 )

• At approximately 1 year of age

abnormal podocyte morphology ( J:237632 )

• glomeruli affected showed podocyte swelling

abnormal podocyte slit diaphragm morphology ( J:237632 )

• glomeruli affected showed severe podocyte effacement by electron microscopy analyses

decreased podocyte number ( J:237632 )

• glomeruli affected showed podocyte loss

glomerulosclerosis ( J:237632 )

• focal segmental glomerulosclerosis (FSGS) at approximately 1 year of age in 4 of 23 mice

• FSGS lesions were present in 2?8% of glomeruli in affected mice

• FSGS was of variable intensity, ranging from small focal lesions with characteristic synechia formation to more globally appearing lesions