Phenotypes Associated with This Genotype

Genotype
MGI:6378626

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Ptpn1^tm1Bpk/Ptpn1^tm1Bpk; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:231906 )

♂ • one mouse at 6 weeks of age shows a microinvasive adenocarcinoma

♂ • mice fed a high-fat diet upon weaning show an increase in the penetrance and number of microinvasive foci of microinvasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:231906 )

♂ • mice show a similar number of prostate ductules affected by intraepithelial neoplasia (mPIN) as single Pten^tm1Hwu conditional mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:231906 )

♂ • one mouse at 6 weeks of age shows a microinvasive adenocarcinoma

♂ • mice fed a high-fat diet upon weaning show an increase in the penetrance and number of microinvasive foci of microinvasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:231906 )

♂ • mice show a similar number of prostate ductules affected by intraepithelial neoplasia (mPIN) as single Pten^tm1Hwu conditional mice

reproductive system

increased prostate gland adenocarcinoma incidence ( J:231906 )

♂ • one mouse at 6 weeks of age shows a microinvasive adenocarcinoma

♂ • mice fed a high-fat diet upon weaning show an increase in the penetrance and number of microinvasive foci of microinvasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:231906 )

♂ • mice show a similar number of prostate ductules affected by intraepithelial neoplasia (mPIN) as single Pten^tm1Hwu conditional mice