Phenotypes Associated with This Genotype

Genotype
MGI:6377674

• Allelic Composition: P4hb^tm1.1Geno/P4hb^tm1.1Geno; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased platelet aggregation ( J:229395 )

• poly(I:C)-treated mice show defects in platelet accumulation at sites of injury laser-induced cremaster arteriole injury

decreased susceptibility to induced thrombosis ( J:229395 )

• poly(I:C)-treated mice show defects in platelet accumulation and fibrin deposition at sites of laser-induced cremaster arteriole injury

hematopoietic system

hematopoietic system phenotype ( J:229395 )

N • poly(I:C)-treated mice exhibit normal blood counts and platelet counts are comparable to controls although slightly lower after poly(I:C) and platelet size is comparable to controls

decreased platelet aggregation ( J:229395 )

• poly(I:C)-treated mice show defects in platelet accumulation at sites of injury laser-induced cremaster arteriole injury