Phenotypes Associated with This Genotype

Genotype
MGI:6377634

• Allelic Composition: Apc^Min/Apc⁺; Col1a1^{tm11(tetO-Nup88)Jvd}/Col1a1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased colon tumor incidence ( J:231166 )

• doxycycline (dox)-treated mice show increased incidence of colon tumors compared to single Apc^Min heterozygotes, but tumor multiplicity or size is unaffected and there is no difference in the multiplicity of small intestinal polyps

• mice in which dox is discontinued 30 days before analysis, show the same incidence of colon tumors as in mice with continuous administration of dox

neoplasm

increased colon tumor incidence ( J:231166 )

• doxycycline (dox)-treated mice show increased incidence of colon tumors compared to single Apc^Min heterozygotes, but tumor multiplicity or size is unaffected and there is no difference in the multiplicity of small intestinal polyps

• mice in which dox is discontinued 30 days before analysis, show the same incidence of colon tumors as in mice with continuous administration of dox