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Phenotypes Associated with This Genotype
Genotype
MGI:6369077
Allelic
Composition		 Tg(Mx1-cre)1Cgn/0
Znrf1tm1Lchs/Znrf1tm1Lchs
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation (10 available)
Znrf1tm1Lchs mutation (0 available); any Znrf1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system physiology ( J:250572 )
• hematopoietic cells display increased resistance to endotoxic and polymicrobial septic shock due to attenuated inflammation

immune system
decreased susceptibility to endotoxin shock ( J:250572 )
• after bacterial lipopolysaccharide (LPS) challenges

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory