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Phenotypes Associated with This Genotype
Genotype
MGI:6368187
Allelic
Composition		 Porcntm1.1Lcm/Porcn+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(rx3-icre)1Mjam/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Porcntm1.1Lcm mutation (0 available); any Porcn mutation (19 available)
Tg(rx3-icre)1Mjam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina pigmentation ( J:218165 )
• mild loss of pigment in the dorsal retina pigmented epithelium of most mice
coloboma ( J:218165 )
• in some mice
microphthalmia ( J:218165 )
• slightly in affected eyes

pigmentation
abnormal retina pigmentation ( J:218165 )
• mild loss of pigment in the dorsal retina pigmented epithelium of most mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory