Phenotypes for H2az2 Porcn MGI:6368185 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Porcn^tm1.1Lcm/Y H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Porcn^tm1.1Lcm mutation (0 available); any Porcn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:218165 )

• in all mice

abnormal craniofacial development ( J:218165 )

• abnormal development of facial primordia

midline cleft upper lip ( J:218165 )

• a mild, fully penetrant median cleft lip

cleft palate ( J:218165 )

vision/eye

coloboma ( J:218165 )

• in some mice

nervous system

abnormal midbrain-hindbrain boundary morphology ( J:218165 )

• in all mice

growth/size/body

midline cleft upper lip ( J:218165 )

• a mild, fully penetrant median cleft lip

cleft palate ( J:218165 )

digestive/alimentary system

cleft palate ( J:218165 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:218165

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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