Phenotypes Associated with This Genotype

Genotype
MGI:6367598

• Allelic Composition: Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi
• Genetic Background: C57BL/6N-Mirc33^tm1.1Wtsi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:267719 )

• premature death, with a median lifespan of 30 weeks compared to 123 weeks in controls

growth/size/body

decreased body weight ( J:267719 )

• mice develop body weight reduction after the 4th month of life

adipose tissue

decreased brown adipose tissue amount ( J:267719 )

• mice show a reduction in brown adipose tissue after the 4th month of life

decreased white adipose tissue amount ( J:267719 )

• mice show a reduction in white adipose tissue after the 4th month of life

decreased fat cell size ( J:267719 )

• mice exhibit smaller adipocytes

behavior/neurological

ataxia ( J:267719 )

• mice develop severe ataxia

hunched posture ( J:267719 )

• mice exhibit abnormal posture characterized by a hunched position

cardiovascular system

abnormal pulmonary artery morphology ( J:267719 )

• mice develop hypertrophy of small pulmonary arteries with thickening of the tunica media

abnormal aorta morphology ( J:267719 )

• aortas exhibit higher amount of elastic fibers indicating aortic fibrosis

abnormal aorta tunica adventitia morphology ( J:267719 )

• fibrotic accumulation in the tunica adventitia

increased aorta wall thickness ( J:267719 )

• medial thickening in the vessel wall of the aorta

abnormal heart morphology ( J:267719 )

• necrotic areas with collagen accumulation are seen in hearts

hypertension ( J:267719 )

• mice develop systemic hypertension, showing higher levels of systemic blood pressure

cellular

increased mitochondrial DNA content ( J:267719 )

• increase in cardiac mitochondrial DNA

decreased mitochondrial size ( J:267719 )

• cardiac mitochondrial size is smaller, with an accumulation of smaller rounded mitochondria in cardiomyocytes

increased mitochondrial number ( J:267719 )

• increase in the number of mitochondria in hearts

homeostasis/metabolism

decreased circulating creatinine level ( J:267719 )

• serum creatinine level is lower

• however, the kidneys do not show any morphological alteration

increased susceptibility to injury ( J:267719 )

• 3 month old mice administered angiotensin II develop more large fibrotic lesions than controls

• 3 month old mice show higher susceptibility to angiotensin II-induced cardiac heart failure, as 40% of mice die during treatment

renal/urinary system

distended urinary bladder ( J:267719 )

• severe bladder distension

abnormal urothelium morphology ( J:267719 )

• the growing pressure inside the bladder is accompanied by urothelium and muscular layer atrophy

ischuria ( J:267719 )

• urinary retention

reproductive system

infertility ( J:267719 )

skeleton

kyphosis ( J:267719 )

• mice develop thoracic kyphosis

vision/eye

ocular hypertension ( J:267719 )

blindness ( J:267719 )

• eye degeneration and blindness