Phenotypes Associated with This Genotype

Genotype
MGI:6364848

• Allelic Composition: Sdc2^{tm1c(KOMP)Wtsi}/Sdc2^{tm1c(KOMP)Wtsi}; Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:276769 )

• reduced postnatal vessel outgrowth with reduced branching in tamoxifen-treated mice

decreased angiogenesis ( J:276769 )

• reduced in the retina of tamoxifen-treated mice with reduced number of tip cells

• however, vessel pruning is normal

decreased vascular endothelial cell proliferation ( J:276769 )

• in tamoxifen-treated mice

vision/eye

abnormal retina vasculature morphology ( J:276769 )

• reduced postnatal vessel outgrowth with reduced branching in tamoxifen-treated mice

cellular

decreased vascular endothelial cell proliferation ( J:276769 )

• in tamoxifen-treated mice

decreased endothelial cell proliferation ( J:276769 )

• in tamoxifen-treated mice