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Phenotypes Associated with This Genotype
Genotype
MGI:6364110
Allelic
Composition
Pianptm1d(KOMP)Wtsi/Pianptm1d(KOMP)Wtsi
Genetic
Background
involves: BALB/cJ * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pianptm1d(KOMP)Wtsi mutation (0 available); any Pianp mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal general exploratory behavior
• increased amphetamine-induced locomotor activity during the first ten minutes of habituation
• reduced nest building scores at 5 h but not 24 h indicating autism-like behavior
• however, mice exhibit normal performance in a sucrose preference test
• reduced immobility in a tail suspension or forced swim test
• reduced exploration of open arms and higher latency to enter open arms in an elevated plus maze
• however, a trend toward increased novelty-induced hypophagia is not significant
• reduced exploration of and increased distance from a novel object
• however, mice exhibit normal novel object recognition
• mice spend less time investigating a novel social partner and novel social odors compared with wild-type mice
• however, mice exhibit a normal preference for a novel social partner
• after object presentation
• higher latency to fall on a rotarod only on the first day of testing
• only on the first day of testing
• mice spend less time investigating and preference for a social partner compared with wild-type mice

nervous system
N
• mice exhibit normal neocortex, corpus callosum-alveus, external capsule, CA1 subregions stratum oriens, stratum pyramidale, stratum radiatum, and stratum lacunosum thickness
• mice exhibit statistically normal neurotransmitter levels in the brain
• of granule cells in the dentate gyrus with no change in proliferation
• increased immature neuronal cells
• thin stratum granulosum and the stratum moleculare
• reduced volume of prefrontal cortex
• however, mice exhibit normal striatum and hippocampus volume
• reduced density
• however, Purkinje cell layer is of normal thickness

cellular
• of granule cells in the dentate gyrus with no change in proliferation
• increased immature neuronal cells

taste/olfaction
N
• mice exhibit normal discrimination of nonsocial odors


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory