Phenotypes Associated with This Genotype

Genotype
MGI:6364110

• Allelic Composition: Pianp^{tm1d(KOMP)Wtsi}/Pianp^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: BALB/cJ * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:279537 )

N • mice exhibit normal general exploratory behavior

enhanced behavioral response to amphetamine ( J:279537 )

• increased amphetamine-induced locomotor activity during the first ten minutes of habituation

abnormal emotion/affect behavior ( J:279537 )

• reduced nest building scores at 5 h but not 24 h indicating autism-like behavior

• however, mice exhibit normal performance in a sucrose preference test

increased coping response ( J:279537 )

• reduced immobility in a tail suspension or forced swim test

increased anxiety-related response ( J:279537 )

• reduced exploration of open arms and higher latency to enter open arms in an elevated plus maze

• however, a trend toward increased novelty-induced hypophagia is not significant

abnormal response to novel object ( J:279537 )

• reduced exploration of and increased distance from a novel object

• however, mice exhibit normal novel object recognition

abnormal response to social novelty ( J:279537 )

• mice spend less time investigating a novel social partner and novel social odors compared with wild-type mice

• however, mice exhibit a normal preference for a novel social partner

increased grooming behavior ( J:279537 )

• after object presentation

enhanced coordination ( J:279537 )

• higher latency to fall on a rotarod only on the first day of testing

increased grip strength ( J:279537 )

• only on the first day of testing

social withdrawal ( J:279537 )

• mice spend less time investigating and preference for a social partner compared with wild-type mice

nervous system

nervous system phenotype ( J:279537 )

N • mice exhibit normal neocortex, corpus callosum-alveus, external capsule, CA1 subregions stratum oriens, stratum pyramidale, stratum radiatum, and stratum lacunosum thickness

N • mice exhibit statistically normal neurotransmitter levels in the brain

increased neuron apoptosis ( J:279537 )

• of granule cells in the dentate gyrus with no change in proliferation

premature neuronal precursor differentiation ( J:279537 )

• increased immature neuronal cells

decreased dentate gyrus size ( J:279537 )

• thin stratum granulosum and the stratum moleculare

abnormal cerebral cortex morphology ( J:279537 )

• reduced volume of prefrontal cortex

• however, mice exhibit normal striatum and hippocampus volume

decreased Purkinje cell number ( J:279537 )

• reduced density

• however, Purkinje cell layer is of normal thickness

thin cerebellar granule layer ( J:279537 )

thin cerebellar molecular layer ( J:279537 )

cellular

increased neuron apoptosis ( J:279537 )

• of granule cells in the dentate gyrus with no change in proliferation

premature neuronal precursor differentiation ( J:279537 )

• increased immature neuronal cells

taste/olfaction

taste/olfaction phenotype ( J:279537 )

N • mice exhibit normal discrimination of nonsocial odors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:279537