Phenotypes Associated with This Genotype

Genotype
MGI:6363627

• Allelic Composition: C1qtnf6^tm1Yiw/C1qtnf6^tm1Yiw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:227217 )

• the frequency of homozygotes obtained from heterozygous matings is less than the expected Mendelian ratio (19.4% versus 25%)

immune system

immune system phenotype ( J:227217 )

N • at 8 weeks of age, mice show normal lymphocyte populations in thymus, spleen and lymph nodes relative to wild-type controls

increased autoantibody level ( J:227217 )

• at 1 year of age, mice produce significantly higher levels of antibodies to IgG- and IgM-type rheumatoid factor (RF) than wild-type controls

increased anti-nuclear antigen antibody level ( J:227217 )

• at 1 year of age, mice produce significantly higher levels of autoantibodies to nuclear antigens (ANAs) than wild-type controls