C1qtnf6^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: C1qtnf6^tm1Yiw
• Name: C1q and tumor necrosis factor related protein 6; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:6343246
• Synonyms: C1qtnf6^-, CTRP6 KO
• Gene: C1qtnf6 Location: Chr15:78407546-78415616 bp, - strand Genetic Position: Chr15, 37.55 cM
• Alliance: C1qtnf6^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227217
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The third exon of the C1qtnf6 gene, which encodes the C1q domain, was replaced with a neomycin-resistance gene (Neo) under the control of a PGK1 promoter. RT-PCR analysis confirmed the absence of C1qtnf6 expression in the spleen of homozygous mutant mice. (J:227217)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C1qtnf6 Mutation: 26 strains or lines available

References

• Original: J:227217 Murayama MA, et al., CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 2015;6:8483
• All: 1 reference(s)