Phenotypes Associated with This Genotype

Genotype
MGI:6361102

• Allelic Composition: \Nus1^tm1Wcsa/\Nus1^tm1Wcsa
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased lung endothelial cell apoptosis ( J:230506 )

• lung endothelial cells treated with Ad-Cre show increased apoptosis

• dolichol phosphate supplementation in the media of lung endothelial cell cultures partially rescues the apoptosis defects

decreased lung endothelial cell proliferation ( J:230506 )

• lung endothelial cells treated with an adenovirus-expressing cre recombinase show reduced proliferation

• dolichol phosphate supplementation in the media of lung endothelial cell cultures partially rescues the proliferation defects

respiratory system

abnormal lung endothelial cell physiology ( J:230506 )

• total dolichol levels in lung endothelial cells treated with an adenovirus-expressing cre (Ad-Cre) recombinase are reduced

• lung endothelial cells show reduced glycosylation of VEGFR2, CD31, and VE-cad and increased ER stress markers

• dolichol phosphate supplementation in the media of lung endothelial cell cultures increases the levels of glycosylated endothelial proteins, indicating rescue of glycosylation defects

increased lung endothelial cell apoptosis ( J:230506 )

• lung endothelial cells treated with Ad-Cre show increased apoptosis

• dolichol phosphate supplementation in the media of lung endothelial cell cultures partially rescues the apoptosis defects

decreased lung endothelial cell proliferation ( J:230506 )

• lung endothelial cells treated with an adenovirus-expressing cre recombinase show reduced proliferation

• dolichol phosphate supplementation in the media of lung endothelial cell cultures partially rescues the proliferation defects