Analysis Tools
mortality/aging
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 die 5 days after tamoxifen injection
|
embryo
|
• yolk sacs show vascular defects in embryos from tamoxifen-treated females at E8.5 and E9.5
|
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 show blood filled jugular lymph sacs at E13.5
|
cardiovascular system
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 show dilation of subcutaneous microvessels and blood filled jugular lymph sacs at E13.
• reduction in vascular density and disorganized vascular networks are seen in embryonic tissues (hindbrain, skin, and hindlimb) of embryos from tamoxifen-treated females at E8.5 and E9.5
|
|
• yolk sacs show vascular defects in embryos from tamoxifen-treated females at E8.5 and E9.5
|
hemorrhage
(
J:230506
)
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 exhibit extensive multifocal subcutaneous hemorrhages at E12.5 and E13.5
|
|
• dorsal skin of embryos from tamoxifen-treated females show increased apoptosis
|
cellular
|
• dorsal skin of embryos from tamoxifen-treated females show increased apoptosis
|
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 show 48% reductions in endothelial cell proliferation at E12.5
|
homeostasis/metabolism
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 exhibit subcutaneous edema
|
immune system
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 show blood filled jugular lymph sacs at E13.5
|
integument
|
• embryos from tamoxifen-treated females at E8.5 and E9.5 exhibit subcutaneous edema
|
