Phenotypes Associated with This Genotype

Genotype
MGI:6361094

• Allelic Composition: Nus1^tm1Wcsa/Nus1^tm1Wcsa; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:230506 )

• lethality between E10.5 and E11.5

growth/size/body

decreased embryo size ( J:230506 )

• embryos are smaller at E10.5 but not at E8.5 or E9.5

embryo

abnormal placenta vasculature ( J:230506 )

• placentas show dilated embryonic vessels and decreased numbers of embryonic vessels

abnormal vitelline vasculature morphology ( J:230506 )

• yolk sacs are poorly organized with dilated primitive capillaries and have no large vitelline vessels

abnormal embryo morphology ( J:230506 )

• E10.5 embryos are paler than controls

decreased embryo size ( J:230506 )

• embryos are smaller at E10.5 but not at E8.5 or E9.5

thin placenta labyrinth ( J:230506 )

• the labyrinthine layers of the placenta are thinner

excessive folding of visceral yolk sac ( J:230506 )

• yolk sacs are dimpled and wrinkled at E9.5

abnormal visceral yolk sac physiology ( J:230506 )

• yolk sacs at E9.5 show 39% reductions in endothelial cell proliferation

• yolk sacs at E9.5 show increased apoptosis of endothelial cells

cardiovascular system

abnormal placenta vasculature ( J:230506 )

• placentas show dilated embryonic vessels and decreased numbers of embryonic vessels

abnormal vitelline vasculature morphology ( J:230506 )

• yolk sacs are poorly organized with dilated primitive capillaries and have no large vitelline vessels

abnormal vascular endothelial cell physiology ( J:230506 )

• hypoglycosylation of endothelial proteins including VEGFR2