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Phenotypes Associated with This Genotype
Genotype
MGI:6360064
Allelic
Composition		 Cd40tm1Kik/Cd40+
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Mir146tm1.1Lfl mutation (1 available); any Mir146 mutation (14 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:266124 )
N
• mice exhibit a restoration of normal IgG1 levels in B cells compared with Mir146tm1.1Tmmc Tg(Cr2-cre)3Cgn mice
increased T follicular helper cell number ( J:266124 )
• following immunization with sheep red blood cells in mixed bone marrow chimeras

hematopoietic system
increased T follicular helper cell number ( J:266124 )
• following immunization with sheep red blood cells in mixed bone marrow chimeras

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory