About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6359451
Allelic
Composition
FanceTg(Tyr)2364E-2a2Ove/FanceTg(Tyr)2364E-2a2Ove
Genetic
Background
FVB/N-FanceTg(Tyr)2364E-2a2Ove/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
FanceTg(Tyr)2364E-2a2Ove mutation (1 available); any Fance mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• very few spermatocytes in tubules at age 3 weeks
• most tubules devoid of spermatocytes at age 4 weeks
• very few mature sperm in tubules at age 8 weeks
• fewer meiotic cells in 20-day old testes

endocrine/exocrine glands
• many tubules show extensive vacuolization between age 3 and 8 weeks

growth/size/body
• 10-15% lower body weight up to age 2 months

reproductive system
• very few spermatocytes in tubules at age 3 weeks
• most tubules devoid of spermatocytes at age 4 weeks
• very few mature sperm in tubules at age 8 weeks
• fewer meiotic cells in 20-day old testes
• many tubules show extensive vacuolization between age 3 and 8 weeks
• 3 out of 8 mice did not produce offspring
• reduced average number of litters sired
• reduced average litter size


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
01/06/2026
MGI 6.24
The Jackson Laboratory