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Phenotypes Associated with This Genotype
Genotype
MGI:6358358
Allelic
Composition		 Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Ightm1Mnz/Igh+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Commd8tm1.1Ksuz mutation (0 available); any Commd8 mutation (15 available)
Ightm1Mnz mutation (5 available); any Igh mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen B cell follicle morphology ( J:278399 )
• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells
• however, B cells are distributed at the B-T boundary after 6 hours

hematopoietic system
abnormal spleen B cell follicle morphology ( J:278399 )
• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells
• however, B cells are distributed at the B-T boundary after 6 hours

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory