Analysis Tools
mortality/aging
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• mice die within 48 hours of birth
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renal/urinary system
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• kidneys have many cysts in the cortex and outer medulla at P0
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• thin kidney cortex at P0
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• kidneys have many cysts in the cortex and outer medulla at P0
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• decreased nephrogenesis, with premature depletion of the progenitor cell population within the cap mesenchyme
• the cap mesenchyme shows fewer proliferating cells, however apoptosis is no different from controls
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• marker analysis shows reduced inductive and differentiation response within the metanephric mesenchyme
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• kidneys lack a well-defined nephrogenic zone at P0
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small kidney
(
J:228872
)
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• kidneys are reduced in size at E13.5 and in newborns
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• kidney weight is lower in newborns
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• nephron structure volume compared to total kidney volume is reduced at E12.5
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• in newborns
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• developing glomeruli volume and average size are reduced at E12.5
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• nascent nephrons reach the renal vesicle stage but do not develop beyond
• kidneys show less developed epithelial structures at E13.5, with embryos having few vesicles and comma-shaped nephron structures
• all stages of nephron development are reduced at P0 and marker analysis shows that nephron induction and specification of proximal nephron segments are impaired at birth
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• the number of S-shaped bodies is reduced at E12.5
• however, renal vesicle number is not different at E12.5
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• the number of comma-shaped bodies is reduced at E12.5
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• decrease in the number of nephrons at P0
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• ureteric bud branching is reduced at E13.5
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growth/size/body
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• kidneys have many cysts in the cortex and outer medulla at P0
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• kidneys have many cysts in the cortex and outer medulla at P0
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