Phenotypes Associated with This Genotype

Genotype
MGI:6356966

• Allelic Composition: Jak2^tm1.1Ble/Jak2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:257910 )

• all mice die around 30 weeks of age

• mice treated with phenylhydrazine to reduce red blood cells without affecting neutrophils show reversion of lethality

hematopoietic system

enlarged spleen ( J:257910 )

extramedullary hematopoiesis ( J:257910 )

• mice exhibit extramedullary hematopoiesis

• however, mice do not develop myelofibrosis

increased megakaryocyte cell number ( J:257910 )

increased erythroid progenitor cell number ( J:257910 )

• bone marrow stem cell populations show an expansion of the erythroid progenitor population within myeloid progenitor cell

• however, long-term and short-term hematopoietic stem cells and multipotent progenitor compositions are not affected

increased megakaryocyte progenitor cell number ( J:257910 )

• bone marrow stem cell populations show an expansion of the megakaryocytic progenitor population within myeloid progenitor cells

abnormal erythrocyte morphology ( J:257910 )

• red blood cell mass is roughly tripled by increasing the absolute whole-body red blood cell number

increased erythrocyte cell number ( J:257910 )

• erythrocytosis

• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of erythroid cells

thrombocytosis ( J:257910 )

increased leukocyte cell number ( J:257910 )

• leukocytosis, including neutrophilia

increased granulocyte number ( J:257910 )

• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of granulocytic cells

increased neutrophil cell number ( J:257910 )

reticulocytosis ( J:257910 )

homeostasis/metabolism

abnormal blood coagulation ( J:257910 )

• moribund mice exhibit widespread large vascular occlusions, prominently in the lungs and kidney

abnormal thrombosis ( J:257910 )

• moribund mice often show symptoms of thrombosis, including low extremity paralysis and coolness, tachycardia, and tachypnea

abnormal cytokine level ( J:257910 )

• increase in several proinflammatory cytokines, including CCL3 and CSF1

immune system

enlarged spleen ( J:257910 )

increased leukocyte cell number ( J:257910 )

• leukocytosis, including neutrophilia

increased granulocyte number ( J:257910 )

• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of granulocytic cells

increased neutrophil cell number ( J:257910 )

abnormal cytokine level ( J:257910 )

• increase in several proinflammatory cytokines, including CCL3 and CSF1

behavior/neurological

limb paralysis ( J:257910 )

• low extremity paralysis in moribund mice

cardiovascular system

abnormal blood vessel morphology ( J:257910 )

• moribund mice exhibit widespread large vascular occlusions, prominently in the lungs and kidney

• mice treated with repeated injections of Ly-6G antibody to reduce the peripheral neutrophil count do not show alternations in vascular occlusions

• mice treated with phenylhydrazine to reduce red blood cells without affecting neutrophils show a reduction in vascular occlusion formation

increased heart rate ( J:257910 )

• tachycardia in moribund mice

respiratory system

tachypnea ( J:257910 )

• tachypnea in moribund mice

growth/size/body

enlarged spleen ( J:257910 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myeloproliferative neoplasm		DOID:2226		J:257910