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Phenotypes Associated with This Genotype
Genotype
MGI:6317339
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (2 available); any Mirc1 mutation (7 available)
Pkd1tm1.1Pcha mutation (0 available); any Pkd1 mutation (151 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:244067 )
N
• mice exhibit attenuated cyst growth and reduced renal fibrosis compared to single Pkd1tm1.1Pcha homozygotes

homeostasis/metabolism
decreased blood urea nitrogen level ( J:244067 )
• mice exhibit lower blood urea nitrogen (BUN) levels compared to single Pkd1tm1.1Pcha homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory