About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6317335
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (2 available); any Mirc1 mutation (7 available)
Pkd1tm1.1Pcha mutation (0 available); any Pkd1 mutation (151 available)
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (151 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:244067 )
N
• renal function and renal interstitial fibrosis are improved compared to conditional Pkd1 compound heterozygotes and mice live past 1 year of age
decreased kidney cell proliferation ( J:244067 )
• mice show a decrease in cyst epithelial cell proliferation compared to conditional Pkd1 compound heterozygotes
kidney cyst ( J:244067 )
• cyst size is reduced compared to conditional Pkd1 compound heterozygotes
decreased kidney weight ( J:244067 )
• kidney weight is reduced compared to conditional Pkd1 compound heterozygotes

cellular
abnormal peroxisome morphology ( J:244067 )
• the number of peroxisomes in the kidneys is reduced compared to conditional Pkd1 compound heterozygotes
decreased kidney cell proliferation ( J:244067 )
• mice show a decrease in cyst epithelial cell proliferation compared to conditional Pkd1 compound heterozygotes
increased fatty acid oxidation ( J:244067 )
• fatty acid oxidation is increased in kidneys compared to conditional Pkd1 compound heterozygotes
abnormal redox activity ( J:244067 )
• reactive oxidative species level is decreased in the kidneys compared to conditional Pkd1 compound heterozygotes

homeostasis/metabolism
increased fatty acid oxidation ( J:244067 )
• fatty acid oxidation is increased in kidneys compared to conditional Pkd1 compound heterozygotes
decreased circulating creatinine level ( J:244067 )
• mice show decreased levels at 3, 7, and 15 weeks of age compared to conditional Pkd1 compound heterozygotes

growth/size/body
kidney cyst ( J:244067 )
• cyst size is reduced compared to conditional Pkd1 compound heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory